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- Title
Pediatric standard-risk AML with fully matched sibling donors: to transplant in first CR or not?
- Authors
Gassas, A.; Afzal, S.; Ishaqi, M. K.; Finkelstein-Shechter, T.; Rojas, M.; Dupuis, A.; Sung, L.; Doyle, J.
- Abstract
Allogeneic hematopoietic SCT (HSCT) for children with standard-risk AML in first CR (CR1) is controversial. We reviewed 32 consecutive children with standard-risk AML who received matched sibling donor HSCT in CR1 from 1995 to 2004. With a median follow-up of 76 months (range: 36–114), 3 year EFS was 0.74 (95% confidence interval (CI): 0.57–0.88) and the overall survival was 0.81 (95% CI: 0.66–0.93). Only one patient died as a result of TRM. Larger studies, such as the MRC-UK 10 and 12, reported 60–62% EFS. Outcome of children with standard-risk AML transplanted from a matched sibling donor in CR1 is very encouraging with minimal toxicity.Bone Marrow Transplantation (2008) 42, 393–396; doi:10.1038/bmt.2008.182; published online 30 June 2008
- Subjects
ACUTE myeloid leukemia; HEMATOPOIETIC stem cell transplantation; BLOOD diseases; JUVENILE diseases; BLOOD donors; TRANSPLANTATION of organs, tissues, etc.
- Publication
Bone Marrow Transplantation, 2008, Vol 42, Issue 6, p393
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/bmt.2008.182