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- Title
Cerebrospinal fluid total tau as a marker of Alzheimer's disease intensity.
- Authors
Sämgård K; Zetterberg H; Blennow K; Hansson O; Minthon L; Londos E
- Abstract
Objectives: The aim of this longitudinal study was to test the hypothesis that CSF biomarkers in AD patients also may be forward-looking measures that are associated not only with the degree and profile of cognitive impairment but also with changes in cognition over time. Methods: Here, we assessed the association of CSF Aß42, T-tau and P-tau with neuropsychological scores of disease severity, as well as the rate of disease progression, in 142 patients with Alzheimer's disease. All patients were part of a 3-year prospective longitudinal treatment study. Results: A more rapid progress in MMSE score reduction was seen in AD patients with T-tau levels higher than the upper quartile (800ng/L) compared with Alzheimer's disease patients with lower T-tau levels (p - 0.008). We also found that individuals with T-tau > 800ng/L performed worse in total scores and especially in memory and orientation when assessed with MMSE and ADAS cog than patients with T-tau <800ng/L. Similar results were obtained for P-tau. No associations were seen between Aß42 and cognitive scores or disease progression. Discussion: These findings support the hypothesis that increased levels of T-tau reflect the intensity of the disease and are associated with a more rapid disease progress. Copyright © 2009 John Wiley & Sons, Ltd.
- Publication
International Journal of Geriatric Psychiatry, 2010, Vol 25, Issue 4, p403
- ISSN
0885-6230
- Publication type
Journal Article
- DOI
10.1002/gps.2353