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- Title
A dual function of NKG2 D ligands in NK-cell activation.
- Authors
Cheney, Elizabeth E.; Wise, Erica L.; Bui, Jack D.; Schreiber, Robert D.; Carayannopoulos, Leonidas N.; Spitzer, Dirk; Zafirova, Biljana; Polic, Bojan; Shaw, Andrey S.; Markiewicz, Mary A.
- Abstract
NK-cell killing requires both the expression of activating receptor ligands and low MHC class I expression by target cells. Here we demonstrate that the expression of any of the murine ligands for the NK-cell activating receptor NKG2 D results in a concomitant reduction in MHC class I expression. We show this both in tumor cell lines and in vivo. NK-cell lysis is enhanced by the decrease in MHC class I expression, suggesting the change is biologically relevant. These results demonstrate that NKG2 D ligand expression on target cells not only allows for activating receptor recognition, but also actively reduces expression of the inhibitory ligand, MHC class I, leading to enhanced recognition and killing by NK cells.
- Publication
European Journal of Immunology, 2012, Vol 42, Issue 9, p2452
- ISSN
0014-2980
- Publication type
Article
- DOI
10.1002/eji.201141849