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- Title
Assessment of β-zone peripapillary atrophy by optical coherence tomography and scanning laserophthalmoscopy imaging in glaucoma patients.
- Authors
Seidensticker, Florian; Reznicek, Lukas; Mann, Thomas; Hübert, Irene; Kampik, Anselm; Ulbig, Michael; Hirneiss, Christoph; SNeubauer, Aljoscha; Kernt, Marcus
- Abstract
Purpose: To assess β-zone peripapillary atrophy (β-PPA) using spectral domain optical coherence tomography (SD-OCT), scanning laser ophthalmoscopy (SLO), and fundus autofluorescence (FAF) imaging in patients with primary open-angle glaucoma with advanced glaucomatous visual field defects. Methods: A consecutive, prospective series of 82 study eyes with primary open-angle glaucoma were included in this study. All study participants underwent a full ophthalmic examination followed by SD-OCT, wide-field SLO, and FAF imaging of the optic nerve head and the peripapillary region. Results: Eighty-four glaucomatous eyes were included in our prospective study. Correlation analyses for horizontally and vertically obtained β-PPA for all three imaging modalities (color SLO, FAF, and SD-OCT) revealed highest correlations between FAF and color SLO (Pearson correlation coefficient: 0.904 [P,0.001] for horizontal β-PPA and 0.786 [P,0.001] for vertical β-PPA). Bland-Altman plotting revealed highest agreements between color SLO and FAF, with -2.1 pixels ±1.96 standard deviation (SD) for horizontal β-PPA, SD: 10.5 pixels and 2.4 pixels ±1.96 SD for vertical β-PPA. Conclusion: β-PPA can be assessed using en-face SLO and cross-sectional SD-OCT imaging. Correlation analyses revealed highest correlations between color SLO and FAF imaging, while correlations between SLO and SD-OCT were weak. A more precise structural definition of β-PPA is needed.
- Subjects
OPTICAL coherence tomography; SCANNING laser ophthalmoscopy; GLAUCOMA; EYE diseases; STANDARD deviations; PATIENTS
- Publication
Clinical Ophthalmology, 2014, Vol 8, p1233
- ISSN
1177-5467
- Publication type
Article
- DOI
10.2147/OPTH.S55751