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- Title
Hypothalamic Obesity following Craniopharyngioma Surgery: Results of a Pilot Trial of Combined Diazoxide and Metformin Therapy.
- Authors
Hamilton, Jill K.; Conwell, Louise S.; Syme, Catriona; Ahmet, Alexandra; Jeffery, Allison; Daneman, Denis
- Abstract
Objective. To assess the effect of combined diazoxide-metformin therapy in obese adolescents treated for craniopharyngioma. Design. A prospective open-label 6-month pilot treatment trial in 9 obese subjects with craniopharyngioma. Diazoxide (2mg/kg divided b.i.d., maximum 200 mg/day) and metformin (1000 mg b.i.d.). Whole body insulin sensitivity index (WBISI) and areaunder- the-curve insulin (AUCins) were calculated. Results. Seven subjects completed: 4M/3F, mean ± SD age 15.4 ± 2.9 years, weight 99.7 ± 26.3 kg, BMI 35.5 ± 5.6 kg/m2, and BMI SDS 2.3 ± 0.3. Two were withdrawn due to vomiting and peripheral edema. Of participants completing the study, the mean ± SD weight gain, BMI, and BMI SDS during the 6 months were reduced compared to the 6 months prestudy (+1.2 ± 5.9 versus +9.5 ± 2.7 kg, P = .004; -0.3 ± 2.3 versus +2.2 ± 1.5 kg/m2, P = .04; -0.04 ± 0.15 versus +0.11 ± 0.08, P = .021, resp.). AUCins correlated with weight loss (r = 0.82, P = .02) and BMI decrease (r = 0.96, P = .009). Conclusion. Combined diazoxide-metformin therapy was associated with reduced weight gain in patients with hypothalamic obesity. AUCins at study commencement predicted effectiveness of the treatment
- Subjects
OVERWEIGHT teenagers; METFORMIN; HYPOTHALAMIC hormones; WEIGHT gain; WEIGHT loss
- Publication
International Journal of Pediatric Endocrinology, 2011, p1
- ISSN
1687-9848
- Publication type
Article
- DOI
10.1155/2011/417949