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- Title
Genetic Variations in the Serotoninergic System Contribute to Body-Mass Index in Chinese Adolescents.
- Authors
Chen, Chunhui; Chen, Wen; Chen, Chuansheng; Moyzis, Robert; He, Qinghua; Lei, Xuemei; Li, Jin; Wang, Yunxin; Liu, Bin; Xiu, Daiming; Zhu, Bi; Dong, Qi
- Abstract
Objective: Obesity has become a worldwide health problem in the past decades. Human and animal studies have implicated serotonin in appetite regulation, and behavior genetic studies have shown that body mass index (BMI) has a strong genetic component. However, the roles of genes related to the serotoninergic (5-hydroxytryptamine,5-HT) system in obesity/BMI are not well understood, especially in Chinese subjects. Subjects and Design: With a sample of 478 healthy Chinese volunteers, this study investigated the relation between BMI and genetic variations of the serotoninergic system as characterized by 136 representative polymorphisms. We used a system-level approach to identify SNPs associated with BMI, then estimated their overall contribution to BMI by multiple regression and verified it by permutation. Results: We identified 12 SNPs that made statistically significant contributions to BMI. After controlling for gender and age, four of these SNPs accounted for 7.7% additional variance of BMI. Permutation analysis showed that the probability of obtaining these findings by chance was low (p = 0.015, permuted for 1000 times). Conclusion: These results showed that genetic variations in the serotoninergic system made a moderate contribution to individual differences in BMI among a healthy Chinese sample, suggesting that a similar approach can be used to study obesity.
- Subjects
HUMAN genetic variation; SEROTONINERGIC mechanisms; BODY mass index; OBESITY; GENETIC polymorphisms; SEROTONIN; PUBLIC health
- Publication
PLoS ONE, 2013, Vol 8, Issue 3, p1
- ISSN
1932-6203
- Publication type
Article
- DOI
10.1371/journal.pone.0058717