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- Title
Quality of Life, Fatigue, and Sleep Problems in Pancreatic Cancer Patients: A Randomized Trial on the Effects of Exercise.
- Authors
Steindorf, Karen; Clauss, Dorothea; Tjaden, Christine; Hackert, Thilo; Herbolsheimer, Florian; Bruckner, Thomas; Schneider, Lutz; Ulrich, Cornelia M.; Wiskemann, Joachim
- Abstract
Background: Improving quality of life (QoL) is an important treatment goal in pancreatic cancer patients. Although the beneficial effects of exercise on QoL are well understood, few studies have investigated more aggressive cancers such as pancreatic cancer. Methods: Within a randomized trial, we assessed the efficacy of 6-month resistance training on physical functioning (primary outcome) and further QoL-related outcomes. 65 pancreatic cancer patients were assigned to home-based training, supervised training, or a usual care control group. Analysis-of-covariance models on changes from baseline to 6 and 3 months were applied. Results: 47 patients completed the intervention period. After 6 months, no effects of resistance training were observed. However, after 3 months, explorative analyses showed significant between-group mean differences (MD) in favor for resistance training for physical functioning (pooled group: MD=11.0; p=0.016; effect size[ES]=0.31), as well as for global QoL (MD=12.1; p=0.016; effect size=0.56), and other outcomes, such as sleep problems and fatigue. Multiple imputation analyses yielded similar results. Home-based and supervised training performed similarly. Conclusion: This first randomized resistance training trial in pancreatic cancer patients indicated clinically relevant improvements in QoL after 3 but not after 6 months. Given the severity of pancreatic cancer, exercise recommendations may already commence at surgery.
- Subjects
PANCREATIC cancer; CANCER patients; RESISTANCE training; PHYSICAL training &; conditioning; QUALITY of life; PANCREATIC surgery
- Publication
Deutsches Ärzteblatt International, 2019, Vol 116, Issue 27/28, p471
- ISSN
1866-0452
- Publication type
Article
- DOI
10.3238/arztebl.2019.0471