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- Title
The mitochondrial SIRT1-PGC-1α axis in podocyte injury.
- Authors
Tsuruoka S; Hiwatashi A; Usui J; Yamagata K; Tsuruoka, Shuichi; Hiwatashi, Akira; Usui, Joichi; Yamagata, Kunihiro
- Abstract
Dysfunction of mitochondria in podocytes is believed to be a trigger of injury and contributes to progressive glomerular sclerosis; however, the mechanisms had not been fully understood. Yuan et al. report involvement of SIRT1 (a homolog of the life-extending gene sir2 in mammals) and PPAR-γ coactivator 1α, a major regulator of oxidative metabolism, in mitochondria during podocyte injury. This information will be important in exploration of the mechanisms and future treatment of glomerular sclerosis.
- Publication
Kidney International, 2012, Vol 82, Issue 7, p735
- ISSN
0085-2538
- Publication type
journal article
- DOI
10.1038/ki.2012.182