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- Title
Human Immunodeficiency Virus (HIV)-Specific Antibody in Cervicovaginal Lavage Specimens Obtained from Women Infected with HIV Type 1.
- Authors
Williams, Selvi B.; Flanigan, Timothy P.; Cu-Uvin, Susan; Mayer, Kenneth; Williams, Pepper; Ettore, Christopher A.; Artenstein, Andrew W.; Duerr, Ann; VanCott, Thomas C.
- Abstract
To evaluate correlates of anti-human immunodeficiency virus (HIV) type 1 (HIV-1) immunoglobulin (Ig) in the genital tract, anti-HIV-gpl20 IgA and IgG titers in cervicovaginal lavage specimens obtained from 104 HIV1-infected women were measured by enzyme-linked immunosorbent assay. Overall, 24% and 94% of women had detectable anti-gpl20 IgA and IgG, respectively. CD4 cell count correlated negatively with total IgA concentration (r = -0.301; P = .0027) and positively with specific IgA activity (anti-gp120 IgA titer/total IgA concentration, r = 0.306; P = .0023). Women with bacterial vaginosis had 5-fold lower anti-gpl20 IgG titer (P = .0042), 5-fold lower total IgG concentration (P ≤ .0001), and 4-fold higher specific IgG activity (P = .0474) compared with women who did not have bacterial vaginosis. Enhanced understanding of correlates of mucosal immunity to HIV-1 may assist in the design of vaccine strategies or in the prevention of vertical transmission of HIV-1.
- Subjects
HIV; VIRAL antibodies
- Publication
Clinical Infectious Diseases, 2002, Vol 35, Issue 5, p611
- ISSN
1058-4838
- Publication type
Article
- DOI
10.1086/342201