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- Title
Association between periodontitis and severe asthma in adults: A case–control study.
- Authors
Soledade‐Marques, Kaliane Rocha; Gomes‐Filho, Isaac Suzart; da Cruz, Simone Seixas; Passos‐Soares, Johelle de Santana; Trindade, Soraya Castro; Cerqueira, Eneida de Moraes Marcílio; Coelho, Julita Maria Freitas; Barreto, Maurício Lima; Costa, Maria da Conceição Nascimento; Vianna, Maria Isabel Pereira; Scannapieco, Frank A.; Cruz, Álvaro Augusto; Souza‐Machado, Adelmir
- Abstract
Objective: To evaluate the association between periodontitis and severe asthma, with participants in treatment for severe asthma, controlled by therapy. Methods: A case–control investigation was performed to compare 130 adults with severe asthma with 130 without asthma. Individuals with periodontitis were those with ≥4 teeth with ≥1 site with probing depth ≥4 mm, clinical attachment level ≥3 mm, and bleeding upon probing at the same site. Severe asthma diagnosis was based on Global Initiative for Asthma criteria. Results: Association between exposure to periodontitis and severe asthma was found: ORcrude = 2.98 (95% CI: 1.74–5.11). When confounders were considered, the association between exposure to periodontitis and severe asthma was maintained: ORadjusted = 3.01–3.25. Individuals with periodontitis had about a threefold increased risk of severe asthma than those without periodontitis. Frequency of periodontitis in participants with severe asthma was greater than that of those without asthma (46.6% <italic>vs</italic> 22.3%, <italic>p </italic>≤<italic> </italic>.05). Conclusions: Association between periodontitis and severe asthma was observed. Further investigation is required to determine the direction of this relationship. It may be causal, but it may also be a consequence of the immunopathological process that characterizes asthma, or else, consequence of the medication used for treatment.
- Subjects
ASTHMA treatment; ASTHMA risk factors; CONFIDENCE intervals; PERIODONTITIS; PERIODONTIUM; PATIENT participation; SEVERITY of illness index; CASE-control method; ODDS ratio; DISEASE complications; ADULTS
- Publication
Oral Diseases, 2018, Vol 24, Issue 3, p442
- ISSN
1354-523X
- Publication type
Article
- DOI
10.1111/odi.12737