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- Title
Assessment of asthma control among different measures and evaluation of functional exercise capacity in children and adolescents with asthma.
- Authors
Natasha Yumi Matsunaga; de Oliveira, Caio; Gianfrancesco, Livea; Oliveira, Marina Simões; dos Santos Simões, Maria Cristina Ribeiro; Morcillo, André Moreno; Ribeiro, José Dirceu; de Oliveira Ribeiro, Maria Angela Gonçalves; Dalbo Contrera Toro, Adyléia Aparecida
- Abstract
Objective: To assess the agreement among asthma control measures and functional exercise capacity in children and adolescents with uncontrolled and controlled asthma. Methods: Children and adolescents with asthma from 7-17 years old were selected, and they were attended in the "Pediatric Pulmonology Outpatient Clinic of State University of Campinas", in Brazil. All patients had asthma control level assessed by Global Initiative for Asthma questionnaire (GINAq), Asthma Control Test (ACT), spirometry and six-minute-walk-test (6MWT). Patients were classifed as uncontrolled or controlled asthma in each test and agreement among measures was assessed by kappa statistics. The ROC curve was calculated for the 6MWT. The spirometric index obtained from spirometry was composed by FEV1, FEV1/FVC and FEF25-75%. Spirometry and 6MWT results were compared between uncontrolled and controlled asthma group by GINAq. Results: Of the 138 subjects included, 78 (56.5%) were male with median age of 11 (7-17) years old. GINAq detected 68.8% of patients with uncontrolled asthma. Moderate agreement (p < 0.001; k = 0.56) and high specifcity (100%) was observed between GINAq and ACT. In 6MWT, the cut-off point of 82.03% of predicted distance was able to distinguish patients with controlled and uncontrolled asthma. Spirometric index presented 73.4% of sensitivity according to GINAq. The results for 6MWT in patients with uncontrolled asthma were the worst of all. Conclusion: This study highlights the importance of assessing more than one measure to differentiate asthma control level. GINAq identifed more patients with uncontrolled asthma and presented moderate agreement with ACT. Spirometric index was associated with uncontrolled asthma according to GINAq. 6MWT was a suitable measure to distinguish patients with controlled and uncontrolled asthma.
- Subjects
CAMPINAS (Sao Paulo, Brazil); BRAZIL; ASTHMA in children; ASTHMA; RECEIVER operating characteristic curves; EXERCISE; ASTHMATICS
- Publication
Brazilian Journal of Pulmonology / Jornal Brasileiro de Pneumologia, 2020, Vol 46, Issue 3, p1
- ISSN
1806-3713
- Publication type
Article
- DOI
10.36416/1806-3756/e20190102