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- Title
Mice deficient in BACE1, the Alzheimer's β-secretase, have normal phenotype and abolished β-amyloid generation.
- Authors
Luo, Yi; Bolon, Brad; Kahn, Steve; Bennett, Brian D.; Babu-Khan, Safura; Denis, Paul; Fan, Wei; Kha, Hue; Zhang, Jianhua; Gong, Yunhua; Martin, Laura; Louis, Jean-Claude; Yan, Qiao; Richards, William G.; Citron, Martin; Vassar, Robert
- Abstract
Mice deficient in BACE1 (beta-site APP cleaving enzyme 1) are healthy, fertile and appear normal in gross anatomy, tissue histology, hematology and clinical chemistry. BACE1-/- mice also hemizygous for an amyloid precursor protein (APP) transgene lack brain β-amyloid (Aβ) and β-secretase-cleaved APP C-terminal fragments (CTFs). These results provide validation of BACE1 as the major β-secretase in vivo and suggest that therapeutic inhibition of BACE1 for the treatment of Alzheimer's disease may be free of mechanism-based toxicity.
- Subjects
GENE targeting; ALZHEIMER'S disease
- Publication
Nature Neuroscience, 2001, Vol 4, Issue 3, p231
- ISSN
1097-6256
- Publication type
Article
- DOI
10.1038/85059