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- Title
Perinatal transmission of hepatitis C virus from human immunodeficiency virus type 1-infected mothers. Women and Infants Transmission Study.
- Authors
Thomas DL; Villano SA; Riester KA; Hershow R; Mofenson LM; Landesman SH; Hollinger FB; Davenny K; Riley L; Diaz C; Tang HB; Quinn TC; Women and Infants Transmission Study; Thomas, D L; Villano, S A; Riester, K A; Hershow, R; Mofenson, L M; Landesman, S H; Hollinger, F B
- Abstract
Antepartum plasma hepatitis C virus (HCV) RNA was quantified in 155 mothers coinfected with HCV and human immunodeficiency virus type 1 (HIV-1), and HCV RNA was serially assessed in their infants. Of 155 singleton infants born to HCV antibody-positive mothers, 13 (8.4%) were HCV infected. The risk of HCV infection was 3.2-fold greater in HIV-1-infected infants compared with HIV-1-uninfected infants (17.1% of 41 vs. 5.4% of 112, P = .04). The median concentration of plasma HCV RNA was higher among the 13 mothers with HCV-infected infants (2.0 x 10(6) copies/mL) than among the 142 mothers with HCV-negative infants (3.5 x 10(5) copies/mL; P < .001), and there were no instances of HCV transmission from 40 mothers with HCV RNA concentrations of < 10(5) copies/mL. Women dually infected with HIV-1 and HCV but with little or no detectable HCV RNA should be reassured that the risk of perinatal transmission of HCV is exceedingly low.
- Publication
Journal of Infectious Diseases, 1998, Vol 177, Issue 6, p1480
- ISSN
0022-1899
- Publication type
journal article
- DOI
10.1086/515315