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- Title
Colonization by Streptococcus pneumoniae among Human Immunodeficiency Virus-Infected Adults: Prevalence of Antibiotic Resistance, Impact of Immunization, and Characterization by Polymerase Chain Reaction with BOX Primers of Isolates from Persistent ...
- Authors
Rodriguez-Barradas, Maria C.; Tharapel, Reena A.; Groover, Jean E.; Giron, Karen P.; Lacke, Christine E.; Houston, Eric D.; Hamill, Richard J.; Steinhoff, Mark C.; Musher, Daniel M.
- Abstract
Pharyngeal colonization by Streptococcus pneumoniae was evaluated in 103 human immunodeficiency virus (HIV)-infected subjects <200 CD4 cells/µL, 57; ⩾200 CD4 cells/µL, 46) and 39 non-HIV-infected controls who were participants in a vaccine study. At baseline, 7%, 20%, and 10% of subjects in the <200 and ⩾200 CD4 cell groups and in the control group were colonized with S. pneumoniae: Rates at 6 months were 23%, 22%, and 0%, respectively. Of 34 isolates from HIV-infected subjects, 25 were penicillin-resistant and 19 were resistant to ⩾3 antimicrobials; of 8 isolates from controls, 1 was resistant. Resistance to trimethoprim-sulfamethoxazole was significantly higher among HIV-infected subjects with <200 CD4 cells/pL than in those with more CD4 cells. Polymerase chain reaction DNA analysis with BOX primers demonstrated that 12 HIV-infected subjects were persistently colonized with the same S. pneumoniae strain for ⩾ 1 month compared with none of the controls. HIV-infected subjects were more likely to be persistent pneumococcal carriers and to carry antibiotic-resistant isolates than were non- HIV-infected subjects.
- Publication
Journal of Infectious Diseases, 1997, Vol 175, Issue 3, p590
- ISSN
0022-1899
- Publication type
Article