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- Title
Lack of T Cell Dysfunction and Programmed Cell Death in Human Immunodeficiency Virus Type 1-Infected Chimpanzees Correlates with Absence of Monocytotropic Variants.
- Authors
Schuitemaker, Hanneke; Meyaard, Linde; Kootstra, Neeltje A.; Dubbes, Rob; Otto, Sigrid A.; Tersmette, Matthijs; Heeney, Jonathan L.; Miedema, Frank
- Abstract
In asymptomatic human immunodeficiency virus (HIV) infection in humans, disturbed T cell functions such as anergy and programmed cell death, thought to result from inappropriate signaling by antigen-presenting cells due to HIV infection, precede increase in virus load, decline in CD4+ T cell numbers, and subsequent disease progression. Here, in 3 long-term HIV-1-infected asymptomatic chimpanzees, antigen-presenting cell function was intact and T cells had normal proliferative capacity with no evidence of HIV-1-associated programmed cell death. Polymerase chain reaction analysis demonstrated low frequencies of cells harboring proviral DNA. Primary virus isolation from the infected animals demonstrated the absence of monocytotropic HIV-1 variants, in concordance with complete insusceptibility of chimpanzee monocytes for HIV-1 infection. Possibly, because of the incapacity of HIV-1 to infect monocytes, systemic immune dysfunction will not occur, contributing to controlled viral replication and maintenance of the asymptomatic state in HIV-infected chimpanzees.
- Publication
Journal of Infectious Diseases, 1993, Vol 168, Issue 5, p1140
- ISSN
0022-1899
- Publication type
Article