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- Title
Donor-derived myelodysplastic syndrome and acute leukaemia after allogeneic haematopoietic stem cell transplantation: incidence, natural history and treatment response.
- Authors
Dietz, Andrew C.; DeFor, Todd E.; Brunstein, Claudio G.; Wagner, John E.
- Abstract
Donor-derived myelodysplastic syndrome/acute leukaemia ( DD- MDS/ AL) is a rare life-threatening complication of allogeneic haematopoietic stem cell ( HSC) transplantation. However, it is unknown whether the risk differs by HSC source. Therefore, we evaluated the incidence of DD- MDS/ AL in 2390 engrafted patients. With a median follow-up of 7·1 years (1-20·8), the incidence of DD- MDS/ AL was 0·53% (95% confidence interval ( CI), 0·01-1·41%], 0·56% (95% CI, 0·01-1·36%) and 0·56% (95% CI, 0·01-1·10%) in recipients of bone marrow ( n = 1117), peripheral blood ( n = 489) and umbilical cord blood ( UCB, n = 784), respectively. While follow-up is shorter in recipients of UCB and peripheral blood, incidence of DD- MDS/ AL is, thus far, similar between HSC sources.
- Subjects
MYELODYSPLASTIC syndromes; ACUTE leukemia; HEMATOPOIETIC stem cell transplantation; DISEASE complications; FOLLOW-up studies (Medicine); GRAFT versus host disease
- Publication
British Journal of Haematology, 2014, Vol 166, Issue 2, p209
- ISSN
0007-1048
- Publication type
Article
- DOI
10.1111/bjh.12847