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- Title
Artificial chromosome transgenesis reveals long-distance negative regulation of rag1 in zebrafish.
- Authors
Jessen, Jason R.; Willett, Catherine E.; Lin, Shuo
- Abstract
Evaluates the ability of the immune system to respond to a number of foreign antigens. Occurrence of V(D)J recombination in immature lymphocytes; Identification of evidences that distal negative regulatory elements are critical to silence inappropriate rag1 expression; Analysis of the abilities of genomic sequences flanking rag1.
- Subjects
IMMUNE system; ANTIGENS; LYMPHOCYTES
- Publication
Nature Genetics, 1999, Vol 23, Issue 1, p15
- ISSN
1061-4036
- Publication type
Article
- DOI
10.1038/12609