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- Title
Short-Term Effects of the Long-Acting Insulin Analog Detemir and Human Insulin on Plasma Levels of Insulin-Like Growth Factor-I and Its Binding Proteins in Humans.
- Authors
Porcellati, Francesca; Rossetti, Paolo; Candeloro, Paola; Lucidi, Paola; Cioli, Patrizia; Andreoli, Anna Marinelli; Ghigo, Ezio; Bolli, Geremia B.; Fanelli, Carmine G.
- Abstract
Objective: The objective of the study was to compare responses of plasma levels of IGF-I and IGF binding proteins (IGFBP-1 and IGFBP-3) induced by human regular insulin (HI) and the long-acting insulin analog detemir (IDet) at doses equivalent with respect to the glucose-lowering effect. Experimental design: Ten nondiabetic subjects (six males, four females; age, 36 ± 7 yr; body mass index, 22.9 ± 2.6 kg/m2) were studied on four randomized occasions with iv infusion of IDet (2 mU/kg . min for 4 h, followed by 4 mU/kg . min for 1 h) or HI (1 mU/kg . min for 4 h, followed by 2 mU/kg . min for 1 h) in euglycemia [plasma glucose (PG), 90 mg/dl] or during stepped hypoglycemia (PG, 90, 78, 66, 54, and 42 mg/dl). Results: PG was maintained at preselected plateaus, without any significant difference between IDet and HI (P > 0.2). Plasma insulin concentrations were on average approximately nine times greater with IDet than HI (749 ± 52 vs. 83 ± 19 muU/ml, respectively). Plasma IGF-I concentrations did not change from baseline during insulin infusion in euglycemia (IDet, 147 ± 16 ng/ml; HI, 155 ± 15 ng/ml) and hypoglycemia (IDet, 163 ±14 ng/ml; HI, 165 ± 14 ng/ml) with no differences between the two insulins (P > 0.2). A similar pattern was observed for plasma IGFBP-3 levels. Insulin infusion resulted in a suppression of plasma IGFBP-1 concentrations with no differences between IDet (baseline, 16.6 ± 3.8 ng/ml; endpoint, 2.0 ± 0.6 ng/ml) and HI (baseline, 16.6 ± 4.1 ng/ml; endpoint, 2.6 ± 1.4 ng/ml) (P > 0.2) and study conditions (P > 0.2). Conclusions: The greater plasma insulin concentrations obtained with IDet exert effects on plasma levels of IGF-I, IGFBP-1, and IGFBP-3 similar to those of HI. Additional studies are needed to confirm these short-term results in patients with diabetes mellitus on long-term treatment with IDet.
- Publication
Journal of Clinical Endocrinology & Metabolism, 2009, Vol 94, Issue 8, p3017
- ISSN
0021-972X
- Publication type
Article
- DOI
10.1210/jc.2008-2838