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- Title
Evaluation of ICA512As in combination with other islet cell autoantibodies at the onset of IDDM.
- Authors
Feeney, Sandra J.; Myers, Mark A.; Mackay, Ian R.; Zimmet, Paul Z.; Howard, Neville; Verge, Charles F.; Rowley, Merrill J.; Feeney, S J; Myers, M A; Mackay, I R; Zimmet, P Z; Howard, N; Verge, C F; Rowley, M J
- Abstract
<bold>Objective: </bold>The ICA512 pancreatic islet autoantigen is a putative tyrosine phosphatase that is co-identified with the earlier described 40-kDa autoantigen. We report the frequency of autoantibodies to islet cell antigen 512 (ICA512As) in recent-onset IDDM and compare this with other islet cell autoantibodies, including those to GAD (GADAs), insulin (IAAs), and islet cell cytoplasm (ICAs) identified by immunofluorescence.<bold>Research Design and Methods: </bold>Sera from 232 children aged between 9 months and 14.9 years collected within 14 days of diagnosis were tested for ICA512As by a radioimmunoprecipitation assay. The results were compared with previously reported data for GADAs (n = 232), IAAs (n = 167), and ICAs (n = 230).<bold>Results: </bold>The frequency of a positive result for ICA512As in children with newly diagnosed IDDM was 60%. The frequency was greater for children with an age of onset between 5 and 10 years (69%) than for children aged < 5 years (49%) and aged between 10 and 15 years (56%). The frequencies for other autoantibody reactivities were 69% for GADAs, 65% for IAAs, and 70% for ICAs. A combination of positive results for ICA512As, GADAs, and IAAs gave a sensitivity for the diagnosis of childhood IDDM of 95%, which was not significantly increased by a positive result for ICAs (96%).<bold>Conclusions: </bold>Our results further establish that positivity in a combination of tests is more valuable for the prediction of IDDM than a result for any single autoantibody and that the age of the patient should be considered when selecting the combination of tests to use.
- Publication
Diabetes Care, 1997, Vol 20, Issue 9, p1403
- ISSN
0149-5992
- Publication type
journal article
- DOI
10.2337/diacare.20.9.1403