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- Title
Isolation of a New Natural Product and Cytotoxic and Antimicrobial Activities of Extracts from Fungi of Indonesian Marine Habitats.
- Authors
Tarman, Kustiariyah; Lindequist, Ulrike; Wende, Kristian; Porzel, Andrea; Arnold, Norbert; Wessjohann, Ludger A.
- Abstract
In the search for bioactive compounds, 11 fungal strains were isolated from Indonesian marine habitats. Ethyl acetate extracts of their culture broth were tested for cytotoxic activity against a urinary bladder carcinoma cell line and for antifungal and antibacterial activities against fish and human pathogenic bacteria as well as against plant and human pathogenic fungi. The crude extract of a sterile algicolous fungus (KT31), isolated from the red seaweed Kappaphycus alvarezii (Doty) Doty ex P.C. Silva exhibited potent cytotoxic activity with an IC50 value of 1.5 μg/mL. Another fungal strain (KT29) displayed fungicidal properties against the plant pathogenic fungus Cladosporium cucumerinum Ell. et Arth. at 50 μg/spot. 2-Carboxy-8-methoxy-naphthalene-1-ol (1) could be isolated as a new natural product.
- Subjects
MARINE fungi; ANTIFUNGAL agents; BIOACTIVE compounds; NATURAL products; MARINE habitats
- Publication
Marine Drugs, 2011, Vol 9, Issue 3, p294
- ISSN
1660-3397
- Publication type
Article
- DOI
10.3390/md9030294