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- Title
Square-pyramidal mononuclear, dinuclear and polymeric copper(II) complexes with (2-pyridinylmethyl)amino derivatives.
- Authors
RICHTER, STEFAN; LÖNNECKE, PETER; BOVAN, DIJANA; MIJATOVIĆ, SANJA; MAKSIMOVIĆ-IVANIĆ, DANIJELA; KALUĐEROVIĆ, GORAN N.; HEY-HAWKINS, EVAMARIE
- Abstract
The coordination behavior of three ligand precursors 2-[(2-pyridinylmethyl) amino]acetic acid hydrochloride, 4-[(2-pyridinylmethyl)amino]benzoic acid hydrochloride and 4-{[2-(pyridin-2-ylmethylamino)ethylamino]methyl}- benzoic acid hydrochloride, HL1·HCl-HL3·HCl, respectively, in copper(II) complexes is described. The complexes were characterized by elemental analysis, ESI mass spectrometry and IR spectroscopy, as well as X-ray structural analysis. The reaction of copper(II) with HL1·HCl in methanol afforded the polymeric complex [{Cu(µ-Cl)2(MeL1-κ²N,N')}n] (1) featuring the methyl ester of L1 (MeL1). With HL2·HCl or HL3·HCl, the dimeric complex [{CuCl(µ-Cl)(HL2-κ2N,N')}2] (2) or the mononuclear complex [CuCl2(HL3-κ³N,N',N'')] (3) were obtained. All complexes exhibited square-pyramidal geometries. In 1, polymeric chains are formed through bridging chlorido ligands without typical hydrogen bonding interaction. Contrarily, the COOH group in 2 is participating in the formation of intermolecular hydrogen bonding forming a supramolecular structure. In 3, intermolecular hydrogen bonding bonding (Cl⋯H(O)) leads to a 1-D polymeric structure. The copper(II) complex 2 diminished viability of human 8505C, MCF-7, 518A2 and SW-480 cell lines. The tumoricidal effect of 2 was realized mainly through caspase-mediated apoptosis.
- Subjects
COPPER; HYDROGEN bonding interactions; BRIDGING ligands; SCHIFF bases; METHYL formate; HYDROGEN bonding; BENZOIC acid
- Publication
Journal of the Serbian Chemical Society, 2023, Vol 88, Issue 12, p1279
- ISSN
0352-5139
- Publication type
Article
- DOI
10.2298/JSC230818072R