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- Title
Vaccination is an integral strategy to combat antimicrobial resistance.
- Authors
Mullins, Liam P.; Mason, Emily; Winter, Kaitlin; Sadarangani, Manish
- Abstract
Multicomponent vaccines are commonly used for bacteria to target many antigens to broaden coverage of the vaccine and prevent vaccine resistance due to mutations; however, identifying multiple conserved and immunogenic antigens is challenging. Non-vaccine approaches include implementation of infection control and antibiotic stewardship policies for the optimal use of existing antibiotics. Which types of bacterial antigens have been investigated for vaccine development and can t... Current bacterial vaccines are demonstrably effective at reducing disease burden and consequently address AMR via reduction of antibiotic usage. Which vaccine platforms have been used for bacterial vaccine development and where might t... Several approaches exist in bacterial vaccines that are currently included in routine immunization schedules, including whole inactivated bacteria, live-attenuated, and subunit vaccines including toxoid and conjugate vaccines.
- Subjects
DRUG resistance in microorganisms; STREPTOCOCCUS pneumoniae; VACCINATION; HAEMOPHILUS diseases; BACTERIAL vaccines; STREPTOCOCCUS pyogenes; CLINICAL trials
- Publication
PLoS Pathogens, 2023, Vol 18, Issue 6, p1
- ISSN
1553-7366
- Publication type
Article
- DOI
10.1371/journal.ppat.1011379