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- Title
Genetic copy number alterations and IL-13 expression differences in papillary thyroid cancers and benign nodules.
- Authors
ZeFei Zhao; Qing Wei; YongJu Zhao; Fukang Sun; Xiaolong Jin
- Abstract
Abstract Thyroid nodules were the extremely common endocrine tumors, in which papillary thyroid carcinomas (PTCs) were the most prevalent endocrine malignancy, representing 80–90% of all thyroid malignancies. It was still a dilemma to discriminate PTCs and benign thyroid nodules. With a new molecular genetics technology of Multiplex ligation-dependent probe amplification (MLPA), we investigated 13 PTC and 14 benign nodule tissue samples. The results showed that PTCs had more genetic copy number alteration than benign nodules (P IL-13) gene obviously identified the great difference between PTCs and benign nodules. Immunohistochemistry also confirmed significantly higher IL-13 expression in the PTCs (P
- Subjects
GENE expression; THYROID cancer; THYROID gland tumors; INTERLEUKIN-13; ENDOCRINE gland cancer; DISEASE prevalence; MOLECULAR genetics; IMMUNOHISTOCHEMISTRY
- Publication
Endocrine (1355008X), 2009, Vol 36, Issue 1, p155
- ISSN
1355-008X
- Publication type
Article
- DOI
10.1007/s12020-009-9206-y