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- Title
Reduction of IGF-binding protein-3 as a potential marker of intra-uterine growth restriction.
- Authors
Méio, Maria Dalva Barbosa Baker; Moreira, Maria Elizabeth Lopes; Sichieri, Rosely; Moura, Aníbal Sanchez
- Abstract
Background: Growth factor-binding proteins influence the growth of infants starting in utero. Adaptation of the fetus to an adverse uterine environment is associated with changes in the growth hormone-growth factor-insulin axis. Aims: To evaluate serum levels of IGF-I and IGFBP-3 in small and appropriate for gestational age newborn infants. Methods: Fifty-four newborn infants, small (SGA, n=28) or appropriate (AGA, n=26) for gestational age were matched by gestational age and sex. Blood was collected on the first day of life, and anthropometric measurements were taken at birth. The serum levels of IGF-I and IGFBP-3 were compared, and correlated with the anthropometric measurements. Results: On the first day of life, mean serum IGFBP-3 levels were significantly lower in SGA babies and correlated with weight, length, head circumference, and ponderal index (weight/length 3) (P<0.0001). In contrast, no associations were found between IGF-I serum levels and these anthropometric measurements. Conclusion: Our data show that SGA babies have significantly reduced IGFBP-3 concentrations at birth.
- Subjects
INSULIN-like growth factor-binding proteins; GROWTH factors; FETAL development; GESTATIONAL age; NEWBORN infants
- Publication
Journal of Perinatal Medicine, 2009, Vol 37, Issue 6, p689
- ISSN
0300-5577
- Publication type
Article
- DOI
10.1515/JPM.2009.122