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- Title
SARS-CoV-2 Breakthrough Infection after mRNA-1273 Booster among CoronaVac-Vaccinated Healthcare Workers.
- Authors
Santi, Theresia; Kamarga, Lina; Samakto, Baringin De; Jo, Juandy
- Abstract
It remains unknown whether the Indonesian healthcare workers (HCWs) who had received two doses of CoronaVac vaccine and one dose of mRNA-1273 booster could be protected during the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron wave. In total, 125 infection-naïve and 10 previously infected HCWs were recruited. The mRNA1273 booster substantially increased titer of anti-SARS-CoV-2 spike protein receptor-binding domain antibodies. However, the monitoring revealed that 34 out of 125 infection-naïve (27.2%) and 3 out of 10 previously infected HCWs (30.0%) were infected during the Omicron wave. All infected HCWs were either asymptomatic or having mild coronavirus disease 2019 (COVID-19) and subsequently fully recovered, supporting the heterologous prime-boost strategy against COVID-19.
- Subjects
SARS-CoV-2; MEDICAL personnel; BREAKTHROUGH infections; COVID-19; BOOSTER vaccines
- Publication
Infection & Chemotherapy, 2022, Vol 54, Issue 4, p774
- ISSN
2093-2340
- Publication type
Article
- DOI
10.3947/ic.2022.0075