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- Title
The Relationship between Triceps Skinfold Thickness and Overall Survival of Pancreas, Bile Duct and Gallbladder Cancer.
- Authors
Jong-In Chang; Joo Kyung Park; Sang-geul Lee; Kwang Hyuk Lee; Kyu Taek Lee; Jong Kyun Lee; Kyunga Kim
- Abstract
Background/Aims Cachexia is frequently seen in pancreatic cancer (70%-80%) and associated with reduced survival, reduced treatment tolerance and reduction in quality of life. In recent studies, low-normal body mass index (BMI) has worse outcome (overall mortality) in cardiovascular, malignant, chronic disease (so-called obesity paradox). Skinfold thickness is strongly associated with body fatness than BMI. The aims of this prospective study were to find out significance of triceps skinfold (TSF) thickness correlation to overall survival (OS) and treatment response in patient with pancreatobiliary tract cancer along with other nutritional and body fatness parameters. Methods This is the prospective cohort study; newly diagnosed unresectable or borderline pancreatic and biliary tract cancers at Samsung Medical Center were enrolled as study patients. TSF using skin thickness caliper was measured on the half of right upper arm in every 3 weeks. BMI, body weight, and weight changes were also tracked along with TSF. The laboratory data and clinical data were monitored. This trial is registered with https:// clinicaltrials.gov (identifier: NCT03637569). Results The total of 310 patients were enrolled and there were 224 patients with pancreatic cancers and 86 patients with biliary tract caners. The first line chemotherapy regimen of pancreatic cancer patients was Gemcitabine/Abraxane or FOLFIRNOX and 19 patients (5.9%) could not receive chemotherapy due to patients' wishes, old age and poor performance status. The first line chemotherapy regimen of biliary tract cancer patients was Gemcitabine/Cisplatin. The median OS of pancreatic cancer and biliary tract cancer were 6.4 and 7.5 months respectively. Initial body weight, TSF and serum albumin level were the independent prognostic factors among the nutritional parameters and initial stage and Eastern Cooperative Oncology Group were also the independent prognostic factors as we can easily expect. Conclusions This study was the first prospective cohort study investigating OS and treatment response correlation to nutritional status in pancreatobiliary tract cancer.
- Subjects
BILIARY tract cancer; SKINFOLD thickness; BODY mass index; TRICEPS; PANCREATIC cancer
- Publication
Gut & Liver, 2019, Vol 13, Issue 6(suppl. 1), p6
- ISSN
1976-2283
- Publication type
Article