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- Title
Low influenza vaccination coverage in subjects with liver cirrhosis. An alert waiting for winter season 2020–2021 during the COVID‐19 pandemic.
- Authors
Stroffolini, Tommaso; Lombardi, Anna; Ciancio, Alessia; Niro, Grazia A.; Colloredo, Guido; Marignani, Massimo; Vinci, Maria; Morisco, Filomena; Babudieri, Sergio; Ferrigno, Luigina; Sagnelli, Evangelista
- Abstract
We have evaluated flu vaccine coverage and variables associated with the lack of vaccination in cirrhotic subjects with particular attention to the cirrhosis etiology. Cirrhotic subjects consecutively referring to eight Italian centers were prospectively enrolled for a 6‐month period in 2019. Subjects were asked if they had received a flu vaccine in the last 12 months. Multiple logistic regression analysis was performed to identify independent predictors of lack of vaccination. A total of 818 cases were recruited. The overall vaccine coverage was 39.6% (26.9% in those younger than 65 years and 51.9% in those older than 64 years; p < 0.001). Age < 65 years (odds ratio [OR] = 2.38; 95% confidence interval [CI] = 1.68–3.36), alcoholic etiology (OR = 2.40; 95% CI = 1.49–3.85), birth abroad (OR = 2.7; 95% CI = 1.10–6.61), and residence in South/Sardinia island (OR = 1.66; 95% CI = 1.14–2.42) all resulted independent predictors of the likelihood of lack of vaccination. The lack of information regarding the vaccine as the reason for no vaccination was reported by 71.4% of foreigners and by 34.7% of natives (p < 0.001). In conclusion, much work still should be done to improve coverage among groups at higher risk of lack of vaccination identified in this survey. The ongoing SARS‐CoV‐2 pandemic may represent one more alert for improving seasonal flu vaccine coverage to avoid further stress to the National Health System. Highlights: Flu vaccine coverage is often perceived less beneficial in patients withliver disease resulting lower among cirrhotic subjects.Flu infection may cause collateral liver damage such as an usually mild and self‐limiting hepatitis and trigger hepatic decompensation in liver disease.Age (<65 years), birth abroad and alcoholic etiology resulted to be independent predictors of the likelihood of lack of flu vaccination in cirrhotic subjects.
- Subjects
SARDINIA (Italy); COVID-19 pandemic; INFLUENZA vaccines; CIRRHOSIS of the liver; INFLUENZA; LOGISTIC regression analysis; MULTIPLE regression analysis
- Publication
Journal of Medical Virology, 2021, Vol 93, Issue 4, p2446
- ISSN
0146-6615
- Publication type
Article
- DOI
10.1002/jmv.26763