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- Title
Amyloids on Membrane Interfaces: Implications for Neurodegeneration.
- Authors
Mahakud, Amaresh Kumar; Shaikh, Jafarulla; Rifa Iqbal, V. V.; Gupta, Abhinav; Tiwari, Anuj; Saleem, Mohammed
- Abstract
Membrane interfaces are vital for various cellular processes, and their involvement in neurodegenerative disorders such as Alzheimer's and Parkinson's disease has taken precedence in recent years. The amyloidogenic proteins associated with neurodegenerative diseases interact with the neuronal membrane through various means, which has implications for both the onset and progression of the disease. The parameters that regulate the interaction between the membrane and the amyloids remain poorly understood. The review focuses on the various aspects of membrane interactions of amyloids, particularly amyloid-β (Aβ) peptides and Tau involved in Alzheimer's and α-synuclein involved in Parkinson's disease. The genetic, cell biological, biochemical, and biophysical studies that form the basis for our current understanding of the membrane interactions of Aβ peptides, Tau, and α-synuclein are discussed.
- Subjects
ALZHEIMER'S disease; PARKINSON'S disease; TAU proteins; ALPHA-synuclein; NEURODEGENERATION; AMYLOID beta-protein; AMYLOID
- Publication
Journal of Membrane Biology, 2022, Vol 255, Issue 6, p705
- ISSN
0022-2631
- Publication type
Article
- DOI
10.1007/s00232-022-00245-x