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- Title
Long survivors after radical cystectomy versus healthy population: propensity score matched analysis of health-related quality of life.
- Authors
Mastroianni, Riccardo; Iannuzzi, Andrea; Ragusa, Alberto; Flammia, Rocco Simone; Tuderti, Gabriele; Anceschi, Umberto; Bove, Alfredo Maria; Brassetti, Aldo; D'Annunzio, Simone; Ferriero, Mariaconsiglia; Misuraca, Leonardo; Proietti, Flavia; Anselmi, Marianna; Guaglianone, Salvatore; Leonardo, Costantino; Papalia, Rocco; Simone, Giuseppe
- Abstract
Purpose: To investigate Health Related Quality of Life (HRQoL) features of long survivors after radical cystectomy (RC) compared to healthy population (HP) control. Methods: Patients with cT2-4/N0/M0 or Bacillus Calmette-Guérine (BCG) failure high-grade non-muscle-invasive bladder cancer (NMIBC) undergoing RC and ileal Orthotopic Neobladder (iON) from 2010 to 2015 were enrolled in "BCa cohort". Patients aged ≥ 18 yrs old, with no previous diagnosis of BCa or any genitourinary cancer disease were included from General Practitioner outpatients and enrolled in "HP cohort". A 1:1 propensity score matched (PSM) analysis was performed, and HRQoL outcomes were collected according to European Organization for Research and Treatment of Cancer (EORTC), and generic (QLQ-C30) questionnaires. Results: A total of 401 patients were enrolled in the study, 99 and 302 in BCa and HP cohorts, respectively. After applying 1:1 PSM analysis 67 patients were included for each group. Analysis of self-reported HRQoL outcomes described a better HRQoL in BCa cohort. Particularly, in the long run patients receiving RC and iON significantly experienced higher global health-status/QoL (p < 0.001), emotional (p = 0.003) and cognitive functioning (p < 0.001) than HP cohort, providing a significantly lower impairment in terms of fatigue (p = 0.004), pain (p = 0.004), dyspnea (p = 0.02) and insomnia (p = 0.005). Conclusions: Long survivors after RC and iON seems to have a major awareness of self-reported HRQoL compared to HP control group.
- Subjects
NON-muscle invasive bladder cancer; MINIMALLY invasive procedures; PROPENSITY score matching; QUALITY of life; GENERAL practitioners; BLADDER cancer
- Publication
World Journal of Urology, 2024, Vol 42, Issue 1, p1
- ISSN
0724-4983
- Publication type
Article
- DOI
10.1007/s00345-024-05187-8