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- Title
Redox Regulation of the Nuclear Receptor.
- Authors
Tanaka, Hirotoshi; Makino, Yuichi; Okamoto, Kensaku; Iida, Takahisa; Yoshikawa, Noritada; Miura, Takanori
- Abstract
Redox regulation is currently considered a mode of signal transduction for coordinated regulation of a variety of cellular processes. Transcriptional regulation of gene expression is also influenced by the cellular redox state, for example, through the oxidoreductive modification of transcription factors. The nuclear receptors act as ligand-dependent transcription factors and are considered to be one of the key regulators of essential biological processes. Using a glucocorticoid receptor as a model, we show that redox regulation of receptor function is one of the dynamic cellular responses to environmental stimuli.Copyright © 2000 S. Karger AG, Basel
- Subjects
NUCLEAR receptors (Biochemistry); OXIDATION-reduction reaction; GENE expression; HEAT shock proteins; PROTEINS
- Publication
Oncology, 2000, Vol 59, p13
- ISSN
0030-2414
- Publication type
Article
- DOI
10.1159/000055282