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- Title
Disease-Free Survival for Patients with Thin Melanomas according to the American Joint Committee on Cancer 8th Edition.
- Authors
Gambra Michel, Luisa Elena; Uña Gorospe, Jon; López Figueroa, Antonio Luis; Mullor Nogales, Raquel; Martínez Cedrés, José Carlos; Cabrera Suárez, Miguel Ángel; Garrido Ríos, Sofía; Hernández Hernández, Noelia; Suárez Hernández, José; Allende Riera, Ana; Fernández-de-Misa Cabrera; Gambra Michel, Luisa Elena; Uña Gorospe, Jon; López Figueroa, Antonio Luis; Mullor Nogales, Raquel; Martínez Cedrés, José Carlos; Cabrera Suárez, Miguel Ángel; Garrido Ríos, Sofía; Hernández Hernández, Noelia; Suárez Hernández, José
- Abstract
<bold>Background: </bold>The recently implemented AJCC 8th edition TNM staging system for malignant melanoma (MM) changed the definition for T1a and T1b tumours.<bold>Objectives: </bold>To analyse differences in disease-free survival (DFS) among patients with thin MM staged according to both AJCC 7th and 8th editions.<bold>Methods: </bold>An observational study including 285 patients with cutaneous thin MM (thickness ≤1 mm). Cases were staged as T1a and T1b using both 7th and 8th editions. Neither regional nor visceral diseases were present at diagnosis. DFS curves were generated according to the Kaplan-Meier method.<bold>Results: </bold>An 8% shift of patients from a T1a towards a T1b stage group was observed after applying the AJCC 8th edition. According to this 8th edition, DFS for T1a patients was significantly longer than for T1b patients (log-rank test; p = 0.005); 5-year DFS for T1a and T1b was 100 and 95%, respectively (Wilcoxon test; p = 0.002). According to the AJCC 7th edition, DFS did not significantly differ for T1a and T1b patients; 5-year DFS for T1a and T1b was 99 and 97%, respectively (p > 0.05).<bold>Conclusions: </bold>The AJCC 8th edition seems to be a better tool for staging thin melanomas.
- Subjects
UNITED States; PROGRESSION-free survival; MELANOMA; LOG-rank test; EDITIONS; CANCER; DEFINITIONS; PROGNOSIS; TUMOR classification
- Publication
Dermatology (10188665), 2019, Vol 235, Issue 4, p334
- ISSN
1018-8665
- Publication type
journal article
- DOI
10.1159/000499652