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- Title
Evolutionary developmental biology: Use it or lose it.
- Authors
Huang, Bau-lin; Mackem, Susan
- Abstract
The author discusse developmental mechanisms underlying deviation from the five digit ground state, and reflect on two studies in the current issue which highlight developmental mechanisms that result in digit reduction in hoofed mammals and in rodents. Topics discussed include early limb bud control during embryonic development, comparison between expression of digit patterning genes and remodelling activity in limbs of embryonic ungulates, and cell death machinery alteration in ungulates.
- Subjects
DEVELOPMENTAL biology; GENE expression; EXTREMITIES (Anatomy); EMBRYOLOGY; UNGULATES; RODENTS; CELL death
- Publication
Nature, 2014, Vol 511, Issue 7507, p34
- ISSN
0028-0836
- Publication type
Article
- DOI
10.1038/nature13509