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- Title
Characterization of the transporterB<sup>0</sup>AT3 (Slc6a17) in the rodent central nervous system.
- Authors
Hägglund, Maria G. A.; Hellsten, Sofie V.; Bagchi, Sonchita; Ljungdahl, Anna; Nilsson, Victor C. O.; Winnergren, Sonja; Stephansson, Olga; Rumaks, Juris; Svirskis, Simons; Klusa, Vija; Schiöth, Helgi B.; Fredriksson, Robert
- Abstract
Background: The vesicular B0AT3 transporter (SLC6A17), one of the members of the SLC6 family, is a transporter for neutral amino acids and is exclusively expressed in brain. Here we provide a comprehensive expression profile of B0AT3 in mouse brain using in situ hybridization and immunohistochemistry. Results: We confirmed previous expression data from rat brain and used a novel custom made antibody to obtain detailed co-labelling with several cell type specific markers. B0AT3 was highly expressed in both inhibitory and excitatory neurons. The B0AT3 expression was highly overlapping with those of vesicular glutamate transporter 2 (VGLUT2) and vesicular glutamate transporter 1 (VGLUT1). We also show here that Slc6a17mRNA is up-regulated in animals subjected to short term food deprivation as well as animals treated with the serotonin reuptake inhibitor fluoxetine and the dopamine/noradrenaline reuptake inhibitor bupropion. Conclusions: This suggests that the B0AT3 transporter have a role in regulation of monoaminergic as well as glutamatergic synapses.
- Subjects
CENTRAL nervous system; SEROTONIN; BRAIN; GLUTAMIC acid; FLUOXETINE
- Publication
BMC Neuroscience, 2013, Vol 14, Issue 1, p1
- ISSN
1471-2202
- Publication type
Article
- DOI
10.1186/1471-2202-14-54