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- Title
Magnetic silica nanoparticle-supported copper complex as an efficient catalyst for the synthesis of novel triazolopyrazinylacetamides with improved antibacterial activity.
- Authors
Asgari, Mohammad Sadegh; Sepehri, Saghi; Bahadorikhalili, Saeed; Ranjbar, Parviz Rashidi; Rahimi, Rahmatollah; Gholami, Ahmad; Kazemi, Aboozar; Khoshneviszadeh, Mehdi; Larijani, Bagher; Mahdavi, Mohammad
- Abstract
A novel superparamagnetic iron oxide modified with copper via 2-aminobenzamide is synthesized by the modification of Fe3O4@SiO2 with amine, followed by the reaction with isatoic anhydride. The catalyst is fully characterized by various methods. The catalytic activity of the catalyst is evaluated in the synthesis of a series of novel N-alkyl-2-aryl-2-(6-oxo-6,7-dihydro[1,2,3]triazolo[1,5-a]pyrazin-5(4H)-yl)acetamide analogs. Antibacterial activity of the synthesized compounds is evaluated. The catalyst is recoverable and shows excellent reusability in 10 sequential runs.
- Subjects
CATALYST synthesis; ACETAMIDE derivatives; CATALYTIC activity; FERRIC oxide; SILICA; COPPER oxide
- Publication
Chemistry of Heterocyclic Compounds, 2020, Vol 56, Issue 4, p488
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-020-02685-6