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- Title
Simple one-pot synthesis of 5-(chloromethyl)isoxazoles from aldoximes and 2,3-dichloro-1-propene.
- Authors
Kondrashov, Evgeniy V.; Shatokhina, Nina S.
- Abstract
A one-pot synthesis of 3-substituted 5-chloromethylisoxazoles from available starting aldoximes and 2,3-dichloro-1-propene, serving both as a solvent and reagent, is proposed. Excess 2,3-dichloro-1-propene is recovered after the reaction. The synthesis is effective for oximes of both aromatic and aliphatic aldehydes.
- Subjects
ISOXAZOLES; AROMATIC aldehydes; ALDOXIMES; NITRILE oxides
- Publication
Chemistry of Heterocyclic Compounds, 2019, Vol 55, Issue 12, p1228
- ISSN
0009-3122
- Publication type
Article
- DOI
10.1007/s10593-019-02606-2