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- Title
In vitro antimicrobial evaluation, effects of halide concentration and hemolysis study of silver-N-heterocyclic carbene complexes.
- Authors
Aher, Sainath; Das, Anamika; Muskawar, Prashant; Osborne, Jabez; Bhagat, Pundlik
- Abstract
The morpholine containing silver complexes were screened for the zone of inhibition, MIC determination, and longevity studies against bacterial growth. The most potent compounds <bold>SC-4</bold> (Silver Complex-4) and <bold>SC-5</bold> inhibited the bacterial growth with MIC of 12.5 and 6.25 µM against <italic>Staphylococcus aureus,</italic> respectively, and 50 µM against <italic>Salmonella enterica</italic> with an efficient growth inhibition up to 21 days with disruption of cell wall as monitored by SEM analysis. The side chain was varied to evaluate the possible changes in antimicrobial effects. The Ag–NHCs <bold>SC-4</bold> and <bold>SC-5</bold> had shown enhanced bactericidal effects due to the synergistic effects of NaCl and Ag–NHCs when studied at 12.5 µM along with 10 g/L NaCl. The complex <bold>SC-5</bold> induced considerable RBC (red blood corpuscles) rupture at 50 µM compared to <bold>IS-5</bold> (imidazolium salt) and directly proportional to concentration.
- Subjects
METAL complexes; HETEROCYCLIC compounds; ANTI-infective agents; HALIDES; MORPHOLINE; SCANNING electron microscopy
- Publication
Research on Chemical Intermediates, 2018, Vol 44, Issue 3, p2099
- ISSN
0922-6168
- Publication type
Article
- DOI
10.1007/s11164-017-3216-9