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- Title
The Application of Kidney Injury Molecule-1 to Determine the Duration Between Shockwave Lithotripsy Sessions.
- Authors
Aydin, Hasan R.; Irkilata, Lokman; Aydin, Mustafa; Daggulli, Mansur; Taskin, Mehmet H.; Demirel, Huseyin C.; Adanur, Senol; Moral, Caner; Atilla, Mustafa K.; Sancaktutar, Ahmet A.
- Abstract
Purpose: We aimed to evaluate the role of kidney injury molecule-1 (KIM-1) in determining the intervals between shockwave lithotripsy (SWL) sessions. Patients and Methods: This was a prospective, controlled study. It included 40 patients with unilateral kidney stones and 40 healthy persons of a similar age group as controls. The patients' midflow urine samples were collected before SWL and 1 hour, 1 day, 1 week, and 1 month after the procedure. Results: The average age in the SWL and control groups was 45 ± 14 and 39 ± 15 years, respectively ( P = 0.336). The average KIM-1 value before SWL was 0.74 ± 0.35 ng/mL, which was significantly higher than that of the control group (0.51 ± 0.14 ng/mL) ( P < 0.001). Similarly, the average values of the urine samples after SWL were higher than those of the control group ( P < 0.001). When the KIM-1 values of the patients given SWL were compared within the group, the KIM-1 values 1 hour (1.06 ± 0.51) and 1 day (0.99 ± 0.67) after the procedure were statistically clearly higher than those before the procedure ( P < 0.001) and statistically clearly higher than those of the control group ( P = 0.005). The KIM-1 values 1 week and 1 month after the procedure were not significantly different than the preprocedure values ( P = 0.652 and P = 0.747, respectively). Conclusion: KIM-1 is a noninvasive biomarker that may be used to show renal damage because of stones and early-stage renal damage linked to SWL. In addition, post-SWL KIM-1 values may be used to determine the interval between SWL sessions.
- Subjects
SHOCK waves; ULTRASONIC lithotripsy; BIOMARKERS; URINALYSIS; KIDNEY failure; KIDNEY stones; SURGERY
- Publication
Journal of Endourology, 2016, Vol 30, Issue 1, p109
- ISSN
0892-7790
- Publication type
Article
- DOI
10.1089/end.2015.0379