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- Title
LKB1 ? A master tumour suppressor of the small intestine and beyond.
- Authors
Yoo, Lina I.; Chung, Daniel C.; Yuan, Junying
- Abstract
Peutz-Jeghers syndrome (PJS) is a rare, inherited intestinal polyposis syndrome that is associated with a significantly increased risk of several types of cancer — particularly those of the gastrointestinal and reproductive systems. Most cases of PJS have been associated with loss-of-function mutations in the ubiquitously expressed LKB1 gene, which encodes a serine/threonine kinase. Recent studies have begun to illustrate the molecular mechanisms by which LKB1 functions as an important new tumour suppressor.
- Subjects
INTESTINAL diseases; CANCER genetics; TUMOR suppressor genes
- Publication
Nature Reviews Cancer, 2002, Vol 2, Issue 7, p529
- ISSN
1474-175X
- Publication type
Article
- DOI
10.1038/nrc843