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- Title
Mid-dose losartan mitigates diabetes-induced hepatic damage by regulating iNOS, eNOS, VEGF, and NF-κB expressions.
- Authors
OLTULU, Fatih; BUHUR, Aylin; GÜREL, Çevik; KUŞÇU, Gökçe Ceren; DAĞDEVİREN, Melih; KARABAY YAVAŞOĞLU, Nefise Ülkü; KÖSE, Timur; YAVAŞOĞLU, Altuğ
- Abstract
Background/aim: Losartan, an antihypertensive drug, is highly preferred in patients with diabetes mellitus (DM) and hypertension because of its retarding effect on diabetic nephropathy. In this study, we investigated the potential therapeutic effect of different doses of losartan on hepatic damage in a streptozotocin (STZ, 50 mg/kg)-induced DM model in rats. Materials and methods: In this study, five different groups were formed: control, DM, low-dose losartan (5 mg/kg), mid-dose losartan (20 mg/kg), and high-dose losartan (80 mg/kg). Liver tissues of experimental groups were evaluated immunohistochemically for TUNEL, iNOS, eNOS, VEGF, and NF-κB pathways. In addition to immunohistochemical analysis, analyses of SOD and MDA, which are oxidative stress markers, were also performed and the results were evaluated together. Results: When biochemical and immunohistochemical findings were evaluated together, it was found that the results obtained from the mid-dose losartan group were closer to those of the control than the other groups. Conclusion: This study indicated that mid-dose losartan administration may have a therapeutic effect by inhibiting apoptosis and regulating iNOS, eNOS, VEGF, and NF-κB protein expressions in DM-induced hepatic damage.
- Subjects
TREATMENT effectiveness; DIABETIC nephropathies; PROTEIN expression; DIABETES; ANGIOTENSIN II
- Publication
Turkish Journal of Medical Sciences, 2019, Vol 49, Issue 5, p1582
- ISSN
1300-0144
- Publication type
Article
- DOI
10.3906/sag-1901-15