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- Title
Crystal Structure and Physicochemical Characteristics of Two Novel Adamantane Derivatives of Sulfonamides.
- Authors
Kovalchukova, O. V.; Kazachenko, V. P.; Tkachev, V. V.; Utenyshev, A. N.; Strakhova, N. N.; Proshin, A. N.
- Abstract
Two derivatives of adamantane benzenesulfamide have been synthesized and studied: N-adamantane-1-yl-2,4,6-trimethyl-benzenesulfamide (1) and N-adamantane-1-yl-4-methoxy-benzenesulfamide (2). Crystal structures 1 and 2 are solved using X-ray diffraction (XRD) analysis. The solubilities of compounds in a phosphate buffer solution with pH 7.4, 1-octanol, and n-hexane are determined at several temperature points using isothermal saturation. The values of Gibbs energy, enthalpy, and entropy of solubility of the compounds at 298 K are determined.
- Subjects
CRYSTAL structure; GIBBS' free energy; BUFFER solutions; ADAMANTANE derivatives; X-ray diffraction; ENTHALPY; HEXANE; SULFONAMIDES
- Publication
Crystallography Reports, 2021, Vol 66, Issue 3, p424
- ISSN
1063-7745
- Publication type
Article
- DOI
10.1134/S1063774521030123