We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Protection of Piglets with Maternally Derived Antibodies from Sows Inoculated with an Attenuated Live Marker Classical Swine Fever Vaccine (Flc-LOM-BErns).
- Authors
Choe, SeEun; Shin, Jihye; Kim, Ki-Sun; Song, Sok; Cha, Ra Mi; Jung, Byung-Il; Hyun, Bang-Hun; Park, Bong-Kyun; An, Dong-Jun
- Abstract
Here, we investigated the protective efficacy provided by passive immunity induced by a classical swine fever (Flc-LOM-BErns) vaccine with the newly developed DIVA (Differentiating Infected from Vaccinated Animals) function. Ten pigs (aged 40–60 days) with maternally derived antibodies (MDAs) obtained from sows inoculated with the Flc-LOM-BErns vaccine were challenged with virulent classical swine fever virus (CSFV). Pigs with an MDA titer of 6 log2 induced by the Flc-LOM-BErns vaccine were fully protected against virulent CSFV challenge but not the pigs with an MDA titer under 5 log2. In addition, Flc-LOM-BErns vaccine-derived MDAs successfully differentiated vaccinated pigs by bovine viral diarrhea virus (BVDV) Erns/CSFV Erns antibody detection, functioning as a DIVA.
- Subjects
CLASSICAL swine fever; BOVINE viral diarrhea virus; CLASSICAL swine fever virus; PIGLETS; SOWS; IMMUNOGLOBULINS
- Publication
Pathogens, 2020, Vol 9, Issue 8, p608
- ISSN
2076-0817
- Publication type
Article
- DOI
10.3390/pathogens9080608