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- Title
Inflammasomes as Targets for Adjuvants.
- Authors
Ivanov, Konstantin; Garanina, Ekaterina; Rizvanov, Albert; Khaiboullina, Svetlana
- Abstract
Inflammasomes are an essential part of the innate immune system. They are necessary for the development of a healthy immune response against infectious diseases. Inflammasome activation leads to the secretion of pro-inflammatory cytokines such as IL-1β and IL-18, which stimulate the adaptive immune system. Inflammasomes activators can be used as adjuvants to provide and maintain the strength of the immune response. This review is focused on the mechanisms of action and the effects of adjuvants on inflammasomes. The therapeutic and prophylaxis significance of inflammasomes in infectious diseases is also discussed.
- Subjects
INFLAMMASOMES; NLRP3 protein; IMMUNE system; COMMUNICABLE diseases; IMMUNE response; BIOCHEMICAL mechanism of action
- Publication
Pathogens, 2020, Vol 9, Issue 4, p252
- ISSN
2076-0817
- Publication type
Article
- DOI
10.3390/pathogens9040252