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- Title
Rho-directed forces in collective migration.
- Authors
Friedl, Peter; Wolf, Katarina; Zegers, Mirjam M.
- Abstract
Collective cell migration depends on multicellular mechanocoupling between leader and follower cells to coordinate traction force and position change. Co-registration of Rho GTPase activity and forces in migrating epithelial cell sheets now shows how RhoA controls leader-follower cell hierarchy, multicellular cytoskeletal contractility and mechanocoupling, to prevent ectopic leading edges and to move the cell sheet forward.
- Subjects
CELL migration; GUANOSINE triphosphatase; CYTOSKELETON; EPITHELIAL cells; ACTOMYOSIN
- Publication
Nature Cell Biology, 2014, Vol 16, Issue 3, p208
- ISSN
1465-7392
- Publication type
Article
- DOI
10.1038/ncb2923