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- Title
Characteristics and analysis of normal and leukemic stem cells: current concepts and future directions.
- Authors
Brendel, C; Neubauer, A
- Abstract
Acute myeloid leukemias (AML) are considered to be clonal disorders involving early hematopoietic progenitor cells. The recent advances in characterization of early stem cells give rise to the question whether it is possible to distinguish healthy progenitors from cells of the leukemic clone in leukemia patients. Differences and similarities in phenotype, genotype and biology are described for leukemic cells and normal hematological progenitors. Recent new insights into human stem cell development offer the perspective that distinction between benign and malignant progenitors might be possible in the future at a very early stage of maturation.
- Subjects
ACUTE myeloid leukemia; HEMATOPOIETIC agents; ANTIGENS; CELL differentiation; COMPARATIVE studies; HEMATOPOIETIC stem cells; RESEARCH methodology; MEDICAL cooperation; RESEARCH; EVALUATION research; MYELOID leukemia; ACUTE diseases
- Publication
Leukemia (08876924), 2000, Vol 14, Issue 10, p1711
- ISSN
0887-6924
- Publication type
journal article
- DOI
10.1038/sj.leu.2401907