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- Title
Molecular analysis of chromosomal breakpoints in three examples of chromosomal translocation involving the TEL gene.
- Authors
Romana, S P; Poirel, H; Della Valle, V; Mauchauffé, M; Coniat, M Busson-Le; Berger, R; Bernard, O A; Romana, S; Busson-Le Coniat, M
- Abstract
The TEL gene is involved in several chromosomal abnormalities of human hematopoietic malignancies. The chromosome 12 breakpoints frequently lie within the fifth intron of the gene, particularly in the most frequent translocation involving TEL, the t(12;21)(p13;q22). In order to search for a peculiar mechanism involved in the genesis of these translocations, we have established the sequence of two t(12;21) and a t(9;12)(q24;p13) breakpoints. Our data do not reveal the involvement of VDJ recombinase activity or Alu sequences but favor the occurrence of staggered breaks and DNA repair activity in the genesis of these translocations.
- Subjects
GENES; CHROMOSOME abnormalities
- Publication
Leukemia (08876924), 1999, Vol 13, Issue 11, p1754
- ISSN
0887-6924
- Publication type
journal article
- DOI
10.1038/sj.leu.2401564