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- Title
<sup>18</sup>F-PSMA-1007 PET in Biochemical Recurrent Prostate Cancer: An Updated Meta-Analysis.
- Authors
Ferrari, Matteo; Treglia, Giorgio
- Abstract
Background. Prostate-specific membrane antigen- (PSMA-) targeted agents labeled with fluorine-18 (18F) have recently become available to evaluate patients with biochemical recurrent prostate cancer (BRPCa) by using positron emission tomography/computed tomography (PET/CT) or positron emission tomography/magnetic resonance imaging (PET/MRI). We performed a systematic review and meta-analysis about the detection rate (DR) of 18F-PSMA-1007 PET/CT or PET/MRI in BRPCa patients. Methods. A comprehensive computer literature search of PubMed/MEDLINE, EMBASE, and Cochrane Library databases for studies published through 17 May 2021 was carried out using the following search algorithm: "PSMA" AND "1007". Only studies providing data on the DR of 18F-PSMA-1007 PET/CTor PET/MRI in BRPCa were included. A random-effects model was used to calculate the pooled DR on a per scan basis. Results. Fifteen articles (853 patients) were selected and included in the systematic review, and ten were included in the quantitative analysis. Most of the studies reported a good DR of 18F-PSMA-1007 PET/CTorPET/MRI in BRPCa including also patients with low prostate-specific membrane antigen (PSA) values. e DR of 18F-PSMA-1007 PET/CTor PET/MRI was dependent on PSA serum values.)e pooled DR was 81.3% (95% confidence interval: 74.6--88%) with statistical heterogeneity. A significant reporting bias (publication bias) was not detected. Conclusions. 18F-PSMA-1007 PET/CTor PET/MRI showed a good DR in BRPCa patients in line with other PSMA-targeted agents.)e DR of 18F-PSMA-1007 PET/CT or PET/MRI is influenced by serum PSA values. These findings should be confirmed by prospective multicentric trials.
- Publication
Contrast Media & Molecular Imaging, 2021, p1
- ISSN
1555-4309
- Publication type
Article
- DOI
10.1155/2021/3502389