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- Title
Physostigmine reversal of diazepam-induced hypnosis. A study in human volunteers.
- Authors
Avant, G R; Speeg, K V Jr; Freemon, F R; Schenker, S; Berman, M L
- Abstract
Under randomized double-blind conditions, 1.00 to 1.67 mg of intravenous physostigmine (Antilirium) reversed sleep induced by administration of 0.102 to 0.238 mg/kg body weight of intravenous diazepam in eight healthy human volunteers. Awakening occurred 330 to 740s after initiation of the physostigmine infusion at a rate of 0.5 mg/min every 4 min. Diazepam plasma levels were not significantly different at the start of either the physostigmine or placebo infusion. Physostigmine did not effect plasma binding of diazepam. Six subjects experienced nausea, and one subject developed an arrhythmia. Physostigmine reverses diazepam-induced hypnosis but causes side-effects requiring cautious administration.
- Subjects
CLINICAL trials; COGNITION disorders; COMPARATIVE studies; DIAZEPAM; HYPNOTISM; RESEARCH methodology; MEDICAL cooperation; PLACEBOS; RESEARCH; STATISTICAL sampling; SLEEP; TIME; EVALUATION research; RANDOMIZED controlled trials; BLIND experiment; PHYSOSTIGMINE
- Publication
Annals of Internal Medicine, 1979, Vol 91, Issue 1, p53
- ISSN
0003-4819
- Publication type
journal article
- DOI
10.7326/0003-4819-91-1-53