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- Title
Border maneuvers: deployment of mucosal immune defenses against Toxoplasma gondii.
- Authors
Cohen, S B; Denkers, E Y
- Abstract
Toxoplasma gondii is a highly prevalent protozoan pathogen that is transmitted through oral ingestion of infectious cysts. As such, mucosal immune defenses in the intestine constitute the first and arguably most important line of resistance against the parasite. The response to infection is now understood to involve complex three-way interactions between Toxoplasma, the mucosal immune system, and the host intestinal microbiota. Productive outcome of these interactions ensures resolution of infection in the intestinal mucosa. Nonsuccessful outcome may result in emergence of proinflammatory damage that can spell death for the host. Here, we discuss new advances in our understanding of the mechanisms underpinning these disparate outcomes, with particular reference to initiators, effectors, and regulators of mucosal immunity stimulated by Toxoplasma in the intestine.
- Subjects
IMMUNE response; TOXOPLASMA gondii; NATURAL immunity; INTESTINAL mucosa; INFECTION treatment; PATHOGENIC protozoa; IMMUNE system
- Publication
Mucosal Immunology (1933-0219), 2014, Vol 7, Issue 4, p744
- ISSN
1933-0219
- Publication type
Article
- DOI
10.1038/mi.2014.25