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- Title
Acupuncture for postprandial distress syndrome: a randomized controlled pilot trial.
- Authors
Tu, Jian-Feng; Yang, Jing-Wen; Wang, Li-Qiong; Zheng, Yang; Zhang, Li-Wen; Li, Yong-Ting; Zhang, Xin; Shi, Guang-Xia; Wang, Jun; Zhao, Jing-Jie; Du, Yi; Chen, San-San; Cheng, Lu; Liu, Cun-Zhi
- Abstract
Background: Evidence for treating postprandial distress syndrome with acupuncture is limited. Aim: We aimed to evaluate the feasibility of verum acupuncture versus sham acupuncture in patients with postprandial distress syndrome. Methods: A total of 42 eligible patients were randomly allocated to either verum acupuncture or sham acupuncture groups in a 1:1 ratio. Each patient received 12 sessions over 4 weeks. The primary outcome was the response rate based on the overall treatment effect (OTE) 4 weeks after randomization. Secondary outcomes included dyspepsia symptom severity and adverse events. Results: In each group, 19 patients (91.5%) completed the study. Thirteen patients receiving verum acupuncture and seven patients receiving sham acupuncture were classified as responders according to OTE (61.9% vs 33.3%; rate difference 28.6%; p = 0.06). Dyspepsia symptom severity at the end of treatment also differed significantly between verum acupuncture and sham acupuncture groups (5.9 units vs 3.7 units; between-group difference 2.2 (95% CI, 0.2–4.2); p = 0.04). No serious adverse events occurred. Conclusion: Four weeks of acupuncture may represent a potential treatment for postprandial distress syndrome. The treatment protocol and outcome measures used in this trial were feasible. Since this was a pilot study, the efficacy of acupuncture still needs to be determined by a larger, adequately powered trial.
- Subjects
CHINA; INDIGESTION treatment; ACADEMIC medical centers; ACUPUNCTURE; CHI-squared test; CONFIDENCE intervals; FISHER exact test; INGESTION; PSYCHOLOGICAL tests; QUALITY of life; QUESTIONNAIRES; RESEARCH funding; STATISTICAL sampling; SCALE analysis (Psychology); STATISTICAL hypothesis testing; T-test (Statistics); PILOT projects; BODY mass index; RANDOMIZED controlled trials; TREATMENT effectiveness; SEVERITY of illness index; DATA analysis software; DESCRIPTIVE statistics; MANN Whitney U Test
- Publication
Acupuncture in Medicine, 2020, Vol 38, Issue 5, p301
- ISSN
0964-5284
- Publication type
Article
- DOI
10.1177/0964528419900911