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- Title
Pre- and Perinatal Factors Predicting Inflammatory Bowel Disease: A Population-Based Study with Fifty Years of Follow-Up.
- Authors
Velosa, Monica; Hochner, Hagit; Yerushalmi, Baruch; Harel, Sasha; Friss, Chagit; Calderon-Margalit, Ronit; Paltiel, Ora; Manor, Orly; Balicer, Ran D; Greenfeld, Shira; Kariv, Revital; Ledderman, Natan; Matz, Eran; Peter, Inga; Friedlander, Yechiel; Turner, Dan
- Abstract
Background Pre- and perinatal events may be associated with an increased risk of inflammatory bowel disease [IBD]. We aimed to investigate the role of pre- and perinatal factors as potential risk factors for the development of IBD in a population with a follow-up of 50 years. Methods We conducted a nested case-control study, reporting IBD incidence among individuals born in 1964–76, for whom pre- and perinatal exposures were reported as part of the Jerusalem Perinatal Study [JPS], by linking them to the database of the epidemiology group of the Israeli IBD Research Nucleus [epi-IIRN], including all IBD patients in Israel since 2005 and their matched controls. Results We identified 2789 individuals within the epi-IIRN cohort who were also included in the JPS cohort [ n = 90 079]: 746 IBD patients (405 with Crohn's disease [CD] and 341 with ulcerative colitis [UC]) and 2043 non-IBD controls. Those with a 'Non-western' family origin had decreased odds of developing CD and UC. High socioeconomic status was associated with CD but not UC. Low birth weight [≤2500 g] occurred less frequently in IBD cases compared to controls, especially in UC patients, showing a protective effect. Being the first born was associated with CD, and having older siblings lowered the odds of developing CD, decreasing 7% with each additional sibling. Smoking and breastfeeding data were available for a subset of individuals, but neither was associated with IBD development. Conclusion This population-based study identifies several pre- and perinatal variables as predictors of IBD development. This information may be helpful to facilitate implementation of early diagnosis interventions and family follow-up protocols.
- Publication
Journal of Crohn's & Colitis, 2022, Vol 16, Issue 9, p1397
- ISSN
1873-9946
- Publication type
Article
- DOI
10.1093/ecco-jcc/jjac043